ASYMMETRIC-SYNTHESIS OF RK-682 AND ITS ANALOGS, AND EVALUATION OF THEIR PROTEIN PHOSPHATASE INHIBITORY ACTIVITIES

Authors
SODEOKA M SAMPE R KAGAMIZONO T OSADA H
Citation
M. Sodeoka et al., ASYMMETRIC-SYNTHESIS OF RK-682 AND ITS ANALOGS, AND EVALUATION OF THEIR PROTEIN PHOSPHATASE INHIBITORY ACTIVITIES, Tetrahedron letters, 37(48), 1996, pp. 8775-8778
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
48
Year of publication
1996
Pages
8775 - 8778
Database
ISI
SICI code
0040-4039(1996)37:48<8775:AORAIA>2.0.ZU;2-J
Abstract
We report an asymmetric synthesis of a potent tyrosine phosphatase inh ibitor, RK-682 and its analogs. The absolute stereochemistry of RK-682 was determined to be (R). The inhibitory activities of RK-682 and its analogs, (R)-1a, (S)-1a, (R)-1b and (R)-1c toward various protein pho sphatases (MIR, cdc25A, cdc25B, and PP1) are also reported. Copyright (C) 1996 Elsevier Science Ltd