TTN OXIDATION OF MIXED HALOGENATED PHENOLS - SYNTHESIS OF VANCOMYCIN MODEL DIARYL ETHER POSSESSING A CHLORINE ATOM

Authors
KONISHI H OKUNO T NISHIYAMA S YAMAMURA S KOYASU K TERADA Y
Citation
H. Konishi et al., TTN OXIDATION OF MIXED HALOGENATED PHENOLS - SYNTHESIS OF VANCOMYCIN MODEL DIARYL ETHER POSSESSING A CHLORINE ATOM, Tetrahedron letters, 37(48), 1996, pp. 8791-8794
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
48
Year of publication
1996
Pages
8791 - 8794
Database
ISI
SICI code
0040-4039(1996)37:48<8791:TOOMHP>2.0.ZU;2-W
Abstract
The diaryl ether possessing a chlorine atom has been synthesized as a model study on a synthesis of vancomycin class glycopeptide antibiotic s. Thallium (III) oxidation of the bisphenol derivative followed by se lective reduction provided the corresponding cyclic product in moderat e overall yield. Conformation of the products is also discussed. Copyr ight (C) 1996 Elsevier Science Ltd