THE NEUROBIOLOGY OF SCHIZOPHRENIA

The hypothesis that altered dopamine function is a major factor in the etiology of schizophrenia has persisted for some time, and changes in other neurochemical systems are strongly implicated as well. These fi ndings are supported by the recent development of new, effective antip sychotic agents, such as clozapine and risperidone, whose actions are attributed to their combined serotonin and dopamine antagonism. In add ition to their clinical efficacy, these agents are associated with sub stantially fewer extrapyramidal adverse effects. Continued research to identify the neurochemical alterations of psychotic diseases will und oubtedly have a favorable impact on the development of improved therap eutic regimens.