More than half a million cases of AIDS have now been reported in the U
nited States. AIDS incidence is rising fastest among women and minorit
y populations, and among persons infected by heterosexual contact or i
ntravenous drug use. Domestically, the impact of HIV/AIDS on nonurban
areas is increasing. Globally,infection rates are rising steeply in so
me countries although being held in check in others. Emerging insights
into the molecular epidemiology of HIV may improve our understanding
of HIV transmission dynamics. Clinicians must participate actively in
promoting interventions proven to be effective in reducing new infecti
ons.