EFFECT OF VARIOUS TYPES OF EXERCISE TRAINING ON 5'-NUCLEOTIDASE AND ADENOSINE-DEAMINASE ACTIVITIES IN RAT-HEART - INFLUENCE OF A SINGLE BOUT OF ENDURANCE EXERCISE

The aim of the present study was to find out whether activities of the enzymes controlling adenosine metabolism, 5'-nucleotidase (5NT) and a denosine deaminase (ADA), in the left ventricle of the rat's heart cha nge after 6 weeks of endurance or sprint training. Additionally, an in fluence of a single bout of endurance exercise till exhaustion on acti vities of these enzymes was investigated in sedentary and trained rats . The rats were divided into three groups: (1) sedentary controls (C), (2) endurance-trained (ET), and (3) sprint-trained (ST). It was shown that both types of training increased 5NT, but did not change ADA act ivity in the rat heart. Acute exercise till exhaustion did not affect 5NT activity in the heart taken from C and ST rats, but decreased its activity in the ET group. The heart ADA activity after exhaustive exer cise increased in C and in ET group, but decreased in ST animals. It i s concluded that physical training affects cardiac adenosine metabolis m and the type of training may exert an influence on purine nucleotide s metabolism in the heart during exhaustive exercise. (C) 1996 Academi c Press, Inc.