CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS

Authors
WARD CM VINOGRADOV DV ANDREWS RK BERNDT MC
Citation
Cm. Ward et al., CHARACTERIZATION OF MOCARHAGIN, A COBRA VENOM METALLOPROTEINASE FROM NAJA MOCAMBIQUE MOCAMBIQUE, AND RELATED PROTEINS FROM OTHER ELAPIDAE VENOMS, Toxicon, 34(10), 1996, pp. 1203-1206
Citations number
10
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
34
Issue
10
Year of publication
1996
Pages
1203 - 1206
Database
ISI
SICI code
0041-0101(1996)34:10<1203:COMACV>2.0.ZU;2-W
Abstract
Mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocam bique, has previously been shown to cleave selectively two mucin-like substrates on platelets and neutrophils within anionic amino acid sequ ences containing sulfated tyrosines, We now show that purified mocarha gin has haemagglutinin activity, and a similar profile for inhibition of mocarhagin-dependent haemagglutination and proteolysis suggests tha t the lectin-like domain may account for its substrate specificity, In addition, immunologically and functionally related proteins were dete cted in other Elapidae venoms. Copyright (C) 1996 Elsevier Science Ltd