EFFECTS OF INTRASTRIATAL INJECTIONS OF PLATELET-ACTIVATING-FACTOR ANDTHE PAF ANTAGONIST BN-52021 ON MEMORY

Citation
Mg. Packard et al., EFFECTS OF INTRASTRIATAL INJECTIONS OF PLATELET-ACTIVATING-FACTOR ANDTHE PAF ANTAGONIST BN-52021 ON MEMORY, Neurobiology of learning and memory, 66(2), 1996, pp. 176-182
Citations number
29
Categorie Soggetti
Psychology,"Behavioral Sciences",Neurosciences,Psychology
ISSN journal
10747427
Volume
66
Issue
2
Year of publication
1996
Pages
176 - 182
Database
ISI
SICI code
1074-7427(1996)66:2<176:EOIIOP>2.0.ZU;2-B
Abstract
The present experiments examined the effects of posttraining intra-dor sal striatal (i.e., caudate-putamen) injections of the phospholipid me thylcarbamyl platelet-activating factor (mc-PAF) and the platelet-acti vating factor (PAF) antagonist BN 52021 on memory using a striatal-dep endent cued water maze task. Male Long-Evans rats received an eight-tr ial training session in which a visibly cued escape platform was locat ed in a different quadrant of the maze on each trial, followed by an i ntrastriatal injection of mc-PAF (0.5, 1.0, or 2.0 mu g/0.5 mu l), BN 52021 (0.25, 0.5, or 1.0 mu g/0.5 mu l), or vehicle (DMSO; 0.5 mu l). On a retention test 24 h later, the escape latencies of rats given mc- PAF (1.0, 2.0 mu g) were significantly lower than those of vehicle-inj ected controls, indicating a memory enhancing effect of mc-PAF. The re tention test escape latencies of rats given BN 52021 (0.5, 1.0 mu g) w ere significantly higher than those of vehicle-injected controls, indi cating a memory impairing effect of BN 52021. Injections of mc-PAF or BN 52021 did not affect retention when administered 2 h posttraining, indicating a time-dependent effect of the drugs on memory storage. The findings indicate a role for endogenous PAF function in striatal-depe ndent memory processes. (C) 1996 Academic Press, Inc.