L. Schofield et Sd. Tachado, REGULATION OF HOST-CELL FUNCTION BY GLYCOSYLPHOSPHATIDYLINOSITOLS OF THE PARASITIC PROTOZOA, Immunology and cell biology, 74(6), 1996, pp. 555-563
Antigenic variation, antigenic drift, molecular mimicry, intracellular
localization and sequestration in privileged sites are important mech
anisms of immune evasion by infectious organisms. Added to this howeve
r is the phenomenon by which pathogens deliberately regulate host cell
function by the production of glycolipids with agonistic or antagonis
tic signal transduction capacity. Such pro-active glycolipids are ofte
n pathogenicity factors, but they also serve as immunomodulators and i
mmunosuppressants, and these activities may serve as mechanisms of imm
une evasion. Here we review glycosylphosphatidylinositols and related
structures, a novel class of glycolipid common to eukaryotic parasites
and their hosts, which recent studies suggest may play a role in immu
ne evasion and immunosuppression by regulating host cell function via
the activation or suppression of endogenous host signalling pathways.