NEUROPROTECTIVE EFFECT OF 4'-(4-METHYLPHENYL)-2,2'-6',2-TERPYRIDINE TRIHYDROCHLORIDE, A NOVEL INDUCER OF NERVE GROWTH-FACTOR

Authors
YAMAMOTO K YOSHIKAWA R OKUYAMA S TAKAHASHI Y KARASAWA Y HINO N MIYOSHI T ARAKI H HANABUSA K SHIRAI H TOMISAWA K
Citation
K. Yamamoto et al., NEUROPROTECTIVE EFFECT OF 4'-(4-METHYLPHENYL)-2,2'-6',2-TERPYRIDINE TRIHYDROCHLORIDE, A NOVEL INDUCER OF NERVE GROWTH-FACTOR, Life sciences, 59(25-26), 1996, pp. 2139-2146
Citations number
35
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
59
Issue
25-26
Year of publication
1996
Pages
2139 - 2146
Database
ISI
SICI code
0024-3205(1996)59:25-26<2139:NEO4T>2.0.ZU;2-F
Abstract
We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydro chloride (SS701), which belongs to a family of a small unique neuropro tective agents. SS701 accelerated the production of nerve growth facto r (NGF) in cultured astroglial cells, dose- and time-dependently. In i n vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongol ian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.