PH-DEPENDENT ACTIONS OF THIP AND ZAPA ON AN IONOTROPIC DROSOPHILA-MELANOGASTER GABA RECEPTOR

Authors
MATSUDA K HOSIE AM BUCKINGHAM SD SQUIRE MD BAYLIS HA SATTELLE DB
Citation
K. Matsuda et al., PH-DEPENDENT ACTIONS OF THIP AND ZAPA ON AN IONOTROPIC DROSOPHILA-MELANOGASTER GABA RECEPTOR, Brain research, 739(1-2), 1996, pp. 335-338
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
739
Issue
1-2
Year of publication
1996
Pages
335 - 338
Database
ISI
SICI code
0006-8993(1996)739:1-2<335:PAOTAZ>2.0.ZU;2-A
Abstract
The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) a nd ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaste r. The amplitude of currents activated by THIP and ZAPA declined rapid ly during agonist application and a rebound response was observed on w ashout. By correcting the pH shift induced by these acid salts, respon ses more typical of GABA agonists were seen. Less striking pH-dependen ce was observed in the case of GABA responses.