HIGH CERULOPLASMIN LEVELS IN RATS WITHOUT HIGH LIPOPROTEIN OXIDATION RATES

The serum copper protein ceruloplasmin, though sometimes considered an antioxidant, can promote lipoprotein oxidation in vitro under certain conditions. However, an inflammation-induced two week elevation of ra t serum ceruloplasmin levels did not render low plus very low density lipoproteins more prone to oxidation in vitro. Thus, high ceruloplasmi n levels in vivo are not necessarily associated with high lipoprotein oxidation rates.