INDONESIAN MEDICINAL-PLANTS .17. CHARACTERIZATION OF QUASSINOIDS FROMTHE STEMS OF QUASSIA-INDICA

Four new quassinoids named samaderines X (1), Y (2), and Z (3), and in daquassin X (5), and a new C-19 quassinoid glycoside, 2-O-glucosylsama derine C (10), together with five known quassinoids, samaderines B (7) , C (8), and E (4), indaquassin C (6), and simarinolide (9), were isol ated from the stems of Quassia indica (Simaroubaceae), an Indonesian m edicinal plant. The chemical structures of these quassinoids have been elucidated on the bases of their chemical and physicochemical propert ies. Samaderines X (1), Z (3), E (4), and B (7) were shown to exhibit significant growth-inhibitory activity against the cultured malarial p arasite Plasmodium falciparum (a chloroquine-resistant K1 strain), and 1-8 were shown to exhibit in vitro cytotoxicity (IC50: 0.04-1.00 mu g /ml) against KB cells. Samaderines X (1), B (7), and C (8), as well as indaquassin X (5), exhibited inhibitory activity in the in vitro endo thelial cell-neutrophil leukocyte adhesion assay, whereas samaderines X (1) and B (7) were found to exhibit significant anti-inflammatory ac tivity.