STUDIES ON THE CONSTITUENTS OF CIMICIFUGA SPECIES .19. 8 NEW GLYCOSIDES FROM CIMICIFUGA-SIMPLEX WORMSK

Eight new glycosides were isolated from Cimicifuga simplex (Ranunculac eae), and their structures were determined to be -didehydroshengmanol- 3-O-alpha-L-arabinipyranoside (1), ehydrohydroshengmanol-3-O-beta-D-ga lactopyranoside (2), ,8-didehydrocimigenol-3-O-beta-D-galactopyranosid e (3), acetylhydroshengmanol-3-O-beta-D-galactopyranoside (4), cimigen ol-3-O-beta-D-galactopyranoside (5), 25-O-methylcimigenol-3-O-beta-D-g alactopyranoside (6), 25-O-acetylcimigenol-3-O-beta-D-galactopyranosid e (7) and 25-O-acetylcimigenol-3-O-beta-D-glucopyranoside (8). Genuine aglycones were obtained by the hydrolysis of 1-7 with lactase F[Amano ] and of 8 with cellulase T[Amano]4. Acerinol was prepared from 7,8-di dehydrocimigenol and showed antilipemic effects.