DESIGN AND SYNTHESIS OF A NEW 4-OXA-8-OMEGA-11-DEOXY-5,6-DIHYDROPROSTACYCLIN ANALOG

Authors
FRAGA CAM MIRANDA ALP BARREIRO EJ
Citation
Cam. Fraga et al., DESIGN AND SYNTHESIS OF A NEW 4-OXA-8-OMEGA-11-DEOXY-5,6-DIHYDROPROSTACYCLIN ANALOG, Chemical and Pharmaceutical Bulletin, 44(11), 1996, pp. 2157-2161
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
11
Year of publication
1996
Pages
2157 - 2161
Database
ISI
SICI code
0009-2363(1996)44:11<2157:DASOAN>2.0.ZU;2-D
Abstract
(+/-)-5-[5 )-1)-2-oxabicyclo[3.3.0]octan-3-yl]-4-oxapentanoic acid (+/ -)-(1a,b), designed as a chemically and biologically stable prostacycl in analogue, was synthesized in 15% yield overall, via the droxymethyl -5-carbethoxy-2-oxabicyclo[3.3.0]octane (4) as the key intermediate.