SYNTHESIS OF THE IMIDAZOLE-DERIVED AT(1)-SELECTIVE ANG-II RECEPTOR ANTAGONIST HR-720 UTILIZING REDUCTIVE AMINATION AS KEY STEP

Authors
HEITSCH H WAHNER A YADAVBHATNAGAR N GRIFFOULMARTEAU C
Citation
H. Heitsch et al., SYNTHESIS OF THE IMIDAZOLE-DERIVED AT(1)-SELECTIVE ANG-II RECEPTOR ANTAGONIST HR-720 UTILIZING REDUCTIVE AMINATION AS KEY STEP, Synthesis, (11), 1996, pp. 1325
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
11
Year of publication
1996
Database
ISI
SICI code
0039-7881(1996):11<1325:SOTIAA>2.0.ZU;2-D
Abstract
The straightforward synthesis of the (1-methylbiphenylsulfonyl)urea su bstituted imidazole HR 720, an orally active ANG II receptor antagonis t, by reductive amination of 2'-sulfonamidobiphenylcarbaldehydes, deri ved from Suzuki-type phenyl-phenyl coupling procedures, as key step is described.