REACTION OF ACTIVE METHYLENE-COMPOUNDS WITH A-FLUOROALKYL KETONES OR ESTERS - A CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRIDINES AND META-TRIFLUOROMETHYLPHENOLS
Hp. Guan et Cm. Hu, REACTION OF ACTIVE METHYLENE-COMPOUNDS WITH A-FLUOROALKYL KETONES OR ESTERS - A CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRIDINES AND META-TRIFLUOROMETHYLPHENOLS, Synthesis, (11), 1996, pp. 1363-1370
The reaction of alpha-fluoroalkyl ketones 1 or ethyl alpha-fluoroalkyl
acetates 2 with active methylene compounds such as methyl acetoacetate
(3), acetylacetone (4) and diethyl malonate (5) produced unsaturated
fluoroalkyl-containing 1,5-dicarbonyl compounds 6, from which polyalky
l-substituted 4-trifluoromethylpyridines 7, 4-trifluoromethylpyrid-2(1
H)-ones 8 and meta-trifluoromethylphenols 9 were synthesized convenien
tly.