REACTION OF ACTIVE METHYLENE-COMPOUNDS WITH A-FLUOROALKYL KETONES OR ESTERS - A CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRIDINES AND META-TRIFLUOROMETHYLPHENOLS

Authors
GUAN HP HU CM
Citation
Hp. Guan et Cm. Hu, REACTION OF ACTIVE METHYLENE-COMPOUNDS WITH A-FLUOROALKYL KETONES OR ESTERS - A CONVENIENT SYNTHESIS OF 4-TRIFLUOROMETHYLPYRIDINES AND META-TRIFLUOROMETHYLPHENOLS, Synthesis, (11), 1996, pp. 1363-1370
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
11
Year of publication
1996
Pages
1363 - 1370
Database
ISI
SICI code
0039-7881(1996):11<1363:ROAMWA>2.0.ZU;2-Q
Abstract
The reaction of alpha-fluoroalkyl ketones 1 or ethyl alpha-fluoroalkyl acetates 2 with active methylene compounds such as methyl acetoacetate (3), acetylacetone (4) and diethyl malonate (5) produced unsaturated fluoroalkyl-containing 1,5-dicarbonyl compounds 6, from which polyalky l-substituted 4-trifluoromethylpyridines 7, 4-trifluoromethylpyrid-2(1 H)-ones 8 and meta-trifluoromethylphenols 9 were synthesized convenien tly.