BIOSYNTHESIS OF ARISTEROMYCIN - THE ROLE OF ,2R,3S,4S)-1-HYDROXYMETHYLCYCLOPENTANE-2,3,4-TRIOL

Authors
HANRAHAN J NAVRATILOVA H SHOBERU KA CROUT DHG HUTCHINSON DW ROBERTS SM WELLINGTON EMH
Citation
J. Hanrahan et al., BIOSYNTHESIS OF ARISTEROMYCIN - THE ROLE OF ,2R,3S,4S)-1-HYDROXYMETHYLCYCLOPENTANE-2,3,4-TRIOL, Journal of the Chemical Society. Perkin transactions. I, (24), 1994, pp. 3533-3536
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
24
Year of publication
1994
Pages
3533 - 3536
Database
ISI
SICI code
0300-922X(1994):24<3533:BOA-TR>2.0.ZU;2-U
Abstract
,2R,3S,4S)-1-Hydroxymethylcyclopentane-2,3,4-triol 2, a possible precu rsor of aristeromycin 1 was synthesised in tritiated form and administ ered to Streptomyces citricolor. Radioactivity was incorporated into a risteromycin, but degradation showed that incorporation of radioactivi ty was nonspecific, indicating that the tetrol 2 is not an immediate p recursor of aristeromycin 1.