ANTHRACYCLINE ANTICANCER DRUGS AS EFFECTIVE LIGANDS FOR TERBIUM(III) IONS

Authors
HAJTAYEB HB FIALLO MML GARNIERSUILLEROT A KISS T KOZLOWSKI H
Citation
Hb. Hajtayeb et al., ANTHRACYCLINE ANTICANCER DRUGS AS EFFECTIVE LIGANDS FOR TERBIUM(III) IONS, Journal of the Chemical Society. Dalton transactions, (24), 1994, pp. 3689-3693
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Dalton transactions → ACNP
ISSN journal
03009246
Issue
24
Year of publication
1994
Pages
3689 - 3693
Database
ISI
SICI code
0300-9246(1994):24<3689:AADAEL>2.0.ZU;2-W
Abstract
Spectroscopic measurements were carried out for terbium(III) complexes with the anthracycline anticancer drugs doxorubicin, aclarubicin, car minomycin and their simple model quinizarin-2-sulfonic acid ydro-1,4-d ihydroxy-9,10-dioxoanthracene-2-sulfonic acid). Potentiometric titrati ons were carried out for the doxorubicin-, aclarubicin- and quinizarin -2-sulfonic acid-containing systems. Both stability constants and CD s pectra indicate that interligand interactions stabilise the 1:2 metal- to-ligand complexes formed.