SYNTHESIS AND HYPOLIPIDEMIC ACTIVITY OF N-PYRIDINYL BORODIPEPTIDYLAMIDES

A series of borodipeptide derivatives 7-9, which contain a 6-amino-2,4 -dimethylpyridine moiety, was prepared in 3 steps. They were evaluated as hypolipidemic agents in rodents at 20 mg/kg per day. The methionin amide and phenylalaninamide derivatives were the most potent compounds demonstrating hypocholesterolemic and hypotriglyceridemic activities in rats. After 14 days, the activity of these compounds was superior t o that of clofibrate, at a dose of 200 mg/kg per day.