A patient with Lyme disease developed an isolated sixth nerve palsy at
the end of a 1 month course of oral antibiotics. Magnetic resonance i
maging disclosed high-signal abnormality at the left pontomedullary ju
nction, implicating involvement of the distal sixth nerve fascicle. Al
though facial numbness ensued during a subsequent course of intravenou
s antibiotics, corticosteroid therapy was associated with prompt impro
vement of neurologic signs, suggesting an immunologic mechanism for th
e central nervous system dysfunction.