When stabilizing fractures with large soft tissue and bone defects, th
e primary concern is to avoid additional vascularization damage. There
fore, external fixation is still the standard method. In metaphysial f
ractures, joint transfixation should be avoided if possible. Concernin
g closed comminuted fractures of femural and tibial shaft fractures, i
nterlocking nailing shows the lowest complication rate. The introducti
on of unreamed nailing of open fractures shows the same low infection
rate as external fixation, so it can be considered an alternative meth
od. Early plate fixation is applied for fractures of the upper extremi
ties as well as the proximal and distal femur, if secure covering with
vital tissue can be provided. As this is not guaranteed in the case o
f the tibial shaft, plate fixation remains the absolute last resort. C
oncerning distal and proximal fractures of the pilon tibiale and tibia
head, plate fixation is very often applied for definitive stabilizati
on. However, the secondary application represents a considerably lower
infection and fracture-healing risk.