ISOLATED HYPERTHERMIA CHEMOTHERAPY PERFUSION FOR LIMB MELANOMA

This article reports on the authors' 38 years of experience with intra -arterial regional chemotherapeutic perfusion of melanoma of the limbs using an extracorporeal oxygenated circuit and a heart-lung machine. Of 1088 patients treated on one occasion, 1,55 had multiple perfusions . The best results have been obtained with recurrent melanoma and intr ansit or nodal metastases of the limb. The method described is useful for adjunctive chemotherapy of poor-risk, stage I melanomas.