REPRODUCTIVE TOXICOLOGY OF THE NEW ANTITUSSIVE MOGUISTEINE

Citation
P. Montaguti et al., REPRODUCTIVE TOXICOLOGY OF THE NEW ANTITUSSIVE MOGUISTEINE, Arzneimittel-Forschung, 44-2(12), 1994, pp. 1347-1352
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
44-2
Issue
12
Year of publication
1994
Pages
1347 - 1352
Database
ISI
SICI code
0004-4172(1994)44-2:12<1347:RTOTNA>2.0.ZU;2-B
Abstract
Moguisteine (R,S(+/-)-2-(2-methoxyphenoxy)-methyl-3- ethoxycarbonylace tyl-1,3-thiazolidine, CAS 119637-67-1), a new oral non narcotic periph erally acting antitussive drug, was examined for effects in the rat on general reproductive performance (at 0, 50, 212, 900 mg/kg/d,) for em bryotoxicity (at 0, 25, 75, 225, 900 mg/kg/d) and for peri-postnatal t oxicity (at 0, 62.5, 250), 1000 mg/kg/d). Embryotoxicity (at 0, 75, 22 5, 900 mg/kg/d) was also examined in the New Zealand White rabbit. In all the studies moguisteine was administered orally as a suspension by gavage. At the tested doses, moguisteine did not interfere with gener al reproductive performance, either in the F0 or in the F1 generation. The drug did not show any toxic effect on the dams and their fetuses, nor did it have any teratogenic effect in either of the tested specie s. Finally moguisteine had no adverse effects either on parturition or on peri- and postnatal survival and/or development of the offspring.