PEROXISOMAL BETA-OXIDATION OF FATTY-ACIDS IN BOVINE AND RAT-LIVER

Hepatic peroxisomal beta-oxidation rates were compared in liver homoge nates from cows and rats during different nutritional and physiologica l states. Peroxisomal oxidation in liver homogenates from cows represe nted 50% and 77% of the total capacity for the initial cycle of beta-o xidation of palmitate and octanoate, respectively, hut only 26% and 65 % for rats. Lactation or food deprivation did not alter rates of hepat ic peroxisomal beta-oxidation of palmitate or octanoate in cows. Fasti ng and clofibrate treatment increased rates of total and peroxisomal b eta-oxidation of palmitate and octanoate in rat liver.