SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF PIDOTIMOD, ITS ENANTIOMER DIASTEREOMERS AND CARBOXAMIDO DERIVATIVES

Authors
MAGNI A SIGNORELLI G BOCCHIOLA G
Citation
A. Magni et al., SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF PIDOTIMOD, ITS ENANTIOMER DIASTEREOMERS AND CARBOXAMIDO DERIVATIVES, Arzneimittel-Forschung, 44-2(12A), 1994, pp. 1402-1404
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
12A
Year of publication
1994
Pages
1402 - 1404
Database
ISI
SICI code
0004-4172(1994)44-2:12A<1402:SAPPEO>2.0.ZU;2-K
Abstract
A new compound with a peptide-like structure, (R)-3[(S)- 2-pyrrolidiny l)carbonyl]-thiazolidine-4-carboxylic acid its enantiomer; diastereome rs and carboxamido derivatives were synthesized and tested for immunos timulant activity. Synthesis, preliminary, pharmacological data and st ructure-activity, relationships are reported. 2-pyrrolidinyl)carbonyl] -thiazolidine-4-carboxylic acid (Ib, Pidotimod, PGT/1A, CAS 121808-62- 6) was selected for further research.