PROTECTIVE EFFECTS OF PIDOTIMOD AGAINST EXPERIMENTAL BACTERIAL-INFECTIONS IN MICE

Pidotimod 5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-car- boxylic a cid, PGT/1A, CAS 121808-62-6) protected mice against experimeental bac terial infections in different experimental models. In all tests the d rug's effect was measured as protection from death. The activity of pi dotimod was evident and statistically significant after 5 administrati ons before the bac- terial challenges. Pidotimod was active against ma ny bacterial species infections, its active dosages ranging from 0.01 to 100 mg/kg i.p. x 5 times. Pidotimod showed against some bacterial i nfections a protection similar or better than those of bestatin, N-ace tylmuramyl-L-Ala-D-isoGlu-OH and tuftsin. It showed high protection ag ainst bacterial infections in cyclophosphamide-immunodepressed mice. F inally, pidotimod showed an additive or synergic activity in combinati on with beta-lactam antibiotics (cefotaxime, ampicillin) against bacte rial infections in mice.