QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-BENZAMIDO-5-NITROTHIAZOLE MOLLUSCICIDAL DERIVATIVES

The pharmacologic action of 2-benzamido-5-nitrothiazole and eleven der ivatives was studied in Lymnaea peregra ovata Muller, Gammarus pulex p ulex L., and Euglena gracilis Klebs. The toxicity parameters (50 % let hal concentration, 50 % inhibitory concentration) were correlated with the physicochemical parameters of the compounds (lipophilicity, stabi lity). The toxicity of the molecule was related to its lipophilicity a nd stability. By combining these parameters it was possible to establi sh specific equations for each species studied. Linear equations of th e overall parameters of the molecule were obtained with L.p. ovata and E. gracilis, whereas second-degree relationships were found with G. p . pulex. Using these pharmacokinetics models, it is possible to predic t the pharmacologic action of these compounds knowing only the physico chemical parameters of each molecule.