IMPACT OF BLOOD-PRESSURE MEASURED IN AMBU LATORY CONDITIONS ON THE 2-YEAR OUTCOME OF MICROALBUMINURIA IN TYPE-1 DIABETIC SUBJECTS

The aim of the present study is the evaluation two years apart of the effect of initial blood pressure values on ambulatory blood pressure d eterminations on the rise of microalbuminuria in 77 Type 1 diabetic pa tients. At the beginning of the study, subjects with incipient nephrop athy have a whole day systolic and diastolic blood pressure greater th an those whose microalbuminuria is below than 30 mg/24 h (127,7 +/- 15 ,1 mmHg versus 115 +/- 14,3 mmHg, p < 0,001; 76,6 +/- 8,1 mmHg versus 72,5 +/- 7,3 mmHg, p < 0,05). Among patients whose initial microalbumi nuria was lower than 30 mg/24 h, incipient nephropathy will not be dep endent on initial blood pressure values but conditioned by patients' a ge and duration diabetes of mellitus. On the other hand, blood pressur e increases the microalbuminuria of the patients who had incipient nep hropathy at the beginning of the study. In patients with diabetes mell itus, ambulatory blood pressure monitoring appreciates the impact of t he pressure rise on the kidney, retina and heart.