Jj. Yohn et al., AUTOREGULATION OF ENDOTHELIN-1 SECRETION BY CULTURED HUMAN KERATINOCYTES VIA THE ENDOTHELIN-B RECEPTOR, Biochimica et biophysica acta. Molecular cell research, 1224(3), 1994, pp. 454-458
We investigated endothelin-1 (ET-1) receptor expression on normal huma
n keratinocytes (HK). We show that HK express the ET(B) receptor isofo
rm and respond to ET-1 with a 2.7-fold increase in intracellular free
calcium. HK did not respond to ET-1 with increased proliferation; howe
ver, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-con
ditioned medium. We propose that HK ET-1 receptors function in autocri
ne regulation of ET-1 secretion.