AUTOREGULATION OF ENDOTHELIN-1 SECRETION BY CULTURED HUMAN KERATINOCYTES VIA THE ENDOTHELIN-B RECEPTOR

Authors
YOHN JJ SMITH C STEVENS T MORELLI JG SHURNAS LR WALCHAK SJ HOFFMAN TA KELLEY KK ESCOBEDOMORSE A YANAGISAWA M KANE MA ZAMORA MR
Citation
Jj. Yohn et al., AUTOREGULATION OF ENDOTHELIN-1 SECRETION BY CULTURED HUMAN KERATINOCYTES VIA THE ENDOTHELIN-B RECEPTOR, Biochimica et biophysica acta. Molecular cell research, 1224(3), 1994, pp. 454-458
Citations number
28
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1224
Issue
3
Year of publication
1994
Pages
454 - 458
Database
ISI
SICI code
0167-4889(1994)1224:3<454:AOESBC>2.0.ZU;2-Z
Abstract
We investigated endothelin-1 (ET-1) receptor expression on normal huma n keratinocytes (HK). We show that HK express the ET(B) receptor isofo rm and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; howe ver, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-con ditioned medium. We propose that HK ET-1 receptors function in autocri ne regulation of ET-1 secretion.