INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS

Authors
KORUTLA L KUMAR R
Citation
L. Korutla et R. Kumar, INHIBITORY EFFECT OF CURCUMIN ON EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE-ACTIVITY IN A431 CELLS, Biochimica et biophysica acta. Molecular cell research, 1224(3), 1994, pp. 597-600
Citations number
26
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1224
Issue
3
Year of publication
1994
Pages
597 - 600
Database
ISI
SICI code
0167-4889(1994)1224:3<597:IEOCOE>2.0.ZU;2-N
Abstract
We explored the mechanism of antigrowth action of Curcumin by investig ating its effect on epidermal growth factor (EGF) receptor intrinsic k inase activity in the human epidermoid carcinoma A431 cells. The short -term treatment of cells with Curcumin inhibited EGF receptor intrinsi c kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular me chanism(s), and preceded the period when inhibition of cell growth occ urred.