COMPLETE ASSIGNMENT OF THE C-13 NMR-SPECTRUM OF VANCOMYCIN

The antibiotic vancomycin has been studied by NMR spectroscopy using m odern, two-dimensional. H-1-C-13 correlation techniques. Working with the fully assigned H-1 spectrum it has been possible, by a series of e xperiments designed to detect direct (one-bond) and indirect (multiple -bond) H-1-C-13 couplings, to assign all 66 carbons of the antibiotic. The assignment was carried out in a DMSO solution and the results the n translated to an aqueous solution by titration.