Although nicotine may be a necessary component of the smoking addictio
n, it is obvious even to the non-expert that there is far more to smok
ing than the delivery of nicotine alone. Among the many aspects of smo
king that smokers find pleasurable, 60% of smokers report liking of th
e feeling of cigarette smoke in the throat and chest. This paper summa
rizes several studies that strongly suggest that the airway sensations
of smoking are important for at least the short-term satisfaction and
craving reduction of cigarette smoking, and that these sensations can
be reproduced by several other substances than cigarette smoke. Airwa
y sensory replacement, especially in combination with nicotine replace
ment, may fill one of the many gaps that currently exist in smoking ce
ssation treatment. (C) 1996 Wiley-Liss, Inc.