HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF BETA-AMINO ALCOHOLS .1. SEPARATION OF (R,S)-1-(DIALKYLAMINO)-2-ALKANOLS ON AN AMYLOSE-BASED CHIRAL STATIONARY-PHASE

Direct enantiomeric separations of racemic mixtures of (R,S)-1-(dialky lamino)-2-alkanols were achieved with a variety of alcohol-modified pe ntane mobile phases and a Chiralpak AD chiral stationary phase. The ef fects of the aliphatic component and the alcohol modifier in the mobil e phase were studied independently. The best separations were obtained with pentane based mobile phases. A variety of alcohol modifiers were investigated that introduced steric factors or affected hydrogen bond ing. Ring size and hetero atom effects of the substituents were noted. Some differences in enantioselectivity between columns were observed.