C. Mainka, THE DEVELOPMENT OF RABIES ANTIBODIES IN F ERRETS AFTER INJECTION OF 4DIFFERENT TYPES OF RABIES VACCINES, Journal of veterinary medicine. Series B, 41(9), 1994, pp. 574-579
The Development of Rabies Antibodies in Ferrets after Injection of Fou
r Different Types of Rabies Vaccines. Experiments aimed at proving the
suitability of ferrets in the routine testing of rabies vaccines for
human and animal use were carried out. A total of 40 ferrets received
four vaccines, two for use in humans and two for use in animals. For t
he determination of rabies antibodies, blood was taken on days 28 and
56, respectively, after inoculation of the vaccines. All animals devel
oped antibodies of more than [0.5 IE/ml] serum as determined by RFFIT.
The antibody titre following injection of the vaccines for animals (A
l and A2) was 4.1 IE/ml on day 28 and 5.86 IE/ml on day 56. The antibo
dy titre following injection of the vaccines for humans was 6.64 IE/ml
on day 28 and 8.87 IE/ml on day 56. The suitability of ferrets for th
e potency assay of rabies vaccines is discussed.