We. Wentworth et al., PULSED DISCHARGE HELIUM IONIZATION DETECTOR UNIVERSAL DETECTOR FOR INORGANIC AND ORGANIC-COMPOUNDS AT THE LOW PICOGRAM LEVEL, Journal of chromatography, 688(1-2), 1994, pp. 135-152
The pulsed discharge helium ionization detector is a universal ionizat
ion detector with sensitivity in the low picogram range. The response
is approximately constant for saturated hydrocarbons on a per gram bas
is. Unsaturated and aromatic hydrocarbons have lower sensitivities, by
about 10-20%. Heterocyclic substituents such as oxygen, chlorine and
bromine tend to lower the response on a per gram basis. The dependence
of the response on various parameters such as pulse interval and powe
r, voltage, flow-rate and detector volume has been investigated. The r
esponse is linearly related to concentration over five orders of magni
tude. The detector volume can be made small enough for high-speed micr
obore chromatography.