LIPASE-CATALYZED TRANSFORMATIONS WITH UNNATURAL ACYL ACCEPTERS

Lipases are readily available and extremely versatile enzymes. Besides their natural reaction - hydrolysis of lipids - lipases catalyze a la rge number of other reactions involving a plethora of acyl accepters s uch as alcohols, amines, ammonia and hydrogen peroxide. They are also able to accommodate a variety of different structures in the acyl dono r. With chiral substrates many of these reactions proceed with a high degree of enantioselectivity. The scope of these lipase-catalyzed tran sformations with different acyl accepters is the subject of this revie w.