D. Chorvatovicova et J. Sandula, EFFECT OF CARBOXYMETHYL-CHITIN-GLUCAN ON CYCLOPHOSPHAMIDE-INDUCED MUTAGENICITY, Mutation research. Mutation research letters, 346(1), 1995, pp. 43-48
The effect of high molecular carboxymethyl-chitin-glucan (CMCG), admin
istered either intraperitoneally, intravenously or orally prior to cyc
lophosphamide injection, on the frequency of micronucleated reticulocy
tes was evaluated in peripheral blood of female ICR mice. Both intrape
ritoneal and intravenous administration of CMCG decreased the clastoge
nic effect of cyclophosphamide. The protective effect of CMCG was conc
entration dependent, with a higher decrease achieved by 100 mg/kg than
by 50 mg/kg body weight. On the other hand, not even five peroral pre
treatments with CMCG in the dose of 200 mg/kg body weight during the w
eek prior to simultaneous administration of CMCG and cyclophosphamide
induced a decrease of micronucleated reticulocytes in peripheral blood
. It is therefore conceivable that CMCG failed to pass through the gas
trointestinal tract, probably due to its high molecular weight. The an
timutagenic effect of CMCG against cyclophosphamide was manifested by
its intraperitoneal and intravenous administration to female ICR mice.