Citation
Ps. Conti et al., HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF C-11 LABELED THYMIDINE AND ITS MAJOR CATABOLITES FOR CLINICAL PET STUDIES, Nuclear medicine and biology, 21(8), 1994, pp. 1045-1051
Citations number
32
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051
→ ACNP
Volume
21
Issue
8
Year of publication
1994
Pages
1045 - 1051
Database
ISI
SICI code
0969-8051(1994)21:8<1045:HLOCLT>2.0.ZU;2-4
Abstract
The identity and pharmacology of the rapidly formed radiolabeled metab
olites formed following i.v. injection of C-11 thymidine (TdR) labeled
in the 5-methyl-position are being studied in animal models and patie
nts with cancer. A high performance liquid chromatographic (HPLC) proc
edure has been developed for the separation of these metabolites inclu
ding thymine, dihydrothymine, beta-ureidoisobutyric acid, and beta-ami
noisobutyric acid from plasma and tissue extracts. Information obtaine
d regarding the pharmacokinetics of the metabolites are being used to
generate mathematical models for C-11 TdR incorporation rates into DNA
.