CYTOGENETIC DAMAGE IN MARROW-CELLS OF MICE AFTER INJECTIONS OF YTTRIUM-90-LABELED MONOCLONAL-ANTIBODY

Chromosome aberrations, micronuclei and sister-chromatid exchanges wer e quantified in marrow cells of athymic nude and B6C3F1 mice at variou s times up to 14 days after injection of Y-90-labeled monoclonal antib ody CO17-1A. Aberrations, predominantly of the chromatid type, were sh arply elevated at 24 h post-injection then declined in a curvilinear f ashion over the 14 days. Micronucleus numbers among polychromatic eryt hrocytes peaked 3-4 days after treatment, then declined exponentially but remained at higher than expected levels. Sister-chromatid exchange s were roughly double the control rate with no apparent relation to po st-treatment time.