ALTERNATIVE METHODS FOR THE DETERMINATION OF TRACE AMOUNTS OF 4-AMINOMORPHOLINE IN MOLSIDOMINE AND LINSIDOMINE

Different methods based on either ion chromatography with electrochemi cal detection or precolumn derivatization with o-phthaldialdehyde were developed to determine trace amounts of 4-aminomorpholine in molsidom ine and linsidomine. Electrochemical detection combined with ion chrom atographic separation revealed outstanding selectivity whereas derivat ization with o-phthaldialdehyde turned out to be very sensitive using RP-HPLC and standard UV detection.