SYNTHESIS AND ANALGESIC ACTIVITY OF 2-AMINO-5-TERT-BUTYL-2-OXAZOLINE

Authors
SERRANO MI SERRANO JS FERNANDEZ A SANCHEZCARRASCO JM FUENTES J PRADERA MA ORTIZ MC FERNANDEZ JMG
Citation
Mi. Serrano et al., SYNTHESIS AND ANALGESIC ACTIVITY OF 2-AMINO-5-TERT-BUTYL-2-OXAZOLINE, Arzneimittel-Forschung, 45-1(1), 1995, pp. 22-26
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-1
Issue
1
Year of publication
1995
Pages
22 - 26
Database
ISI
SICI code
0004-4172(1995)45-1:1<22:SAAAO2>2.0.ZU;2-K
Abstract
2-Amino-5-tert-butyl-2-oxazoline (ATBO, 2) was synthetized from 3,3-di methyl-2-iodobutyl isocyanate via N-(3,3-dimethyl-2-iodobutyl)urea (1) . The structures of compounds 1 and 2 are based on analytical and spec troscopic data. Compound 2 induced in rats and mice a peripheral antin ociceptive effect through both spinal and supraspinal mechanisms. ATBO did not impair motor coordination or activity of the experimental ani mals.