QUALITY OF CEFOTAXIME SODIUM PREPARATIONS

Cefotaxime sodium (CAS 64485-93-4) is a semisynthetic cephalosporin de rivative belonging to the third-generation cephalosporins. Owing to it s broad antibacterial activity and its high resistance to beta-lactama ses it can be used for a large variety of infections. In the present s tudy the quality standard of 15 different cefotaxime sodium manufactur ers from 9 different countries has been examined. The best results wer e received for the preparation Claforan(R). None of the 14 other produ cts showed comparable results especially with respect to particulate m atter and by-products. The particulate contamination of the 14 foreign products showed relatively high values although they still comply wit h the limits set by the pharmacopoeias. In contrast, in Claforan very few particles were found in the solution.