COMPOSITES OF HYDROXYAPATITE AND BISPHOSPHONATE - PROPERTIES AND ALVEOLAR BONE RESPONSE

A composite was made by adsorption of the bisphosphonate hylamino-1-hy droxypropylidene)-1,1-bisphosphonate; dimethyl-APD] into an hydroxyapa tite (HA) tube. Adsorbed dimethyl-APD did not change the bulk properti es of the HA tube but the surface properties were altered. The amount of 0.1 mmol/L dimethyl-APD adsorbed into the HA tube was 0.78 (+/- 0.2 0) mu g after 4 weeks. The composite tube of HA and dimethyl-APD place d after extraction of teeth in the premolar regions of dogs were bioco mpatible, stable and bonded strongly and intimately to the alveolar bo ne. Although there was no bone resorption around the composite tubes, no conclusion can be drawn yet from this study as far as local inhibit ion of alveolar bone resorption is concerned.