F. Olivennes et al., OVARIAN STIMULATION WITH A PROTOCOL USING A LOW-DOSE OF GNRH AGONIST IN PATIENTS WITH ELEVATED BASAL FSH, Contraception fertilite sexualite, 24(12), 1996, pp. 912-916
This study compare the ovarian response of patients with high day 3 FS
H (> 6,5 UI/L), treated with two protocols; a protocol with a low dose
of GnRH agonist and a so called ''long protocol'' with GnRH agonist i
n a depot formula. The ovarian response with the agonist low dose was
better with less ampules (37, 1 vs 46,6) and a shorter duration of sti
mulation (10,5 vs 12,4 days). The number of mature oocyte was higher (
5,9 vs 4,5) as well as the number of good quality embryo (3,2 versus 2
,3). The E2 levels on day 8 was also higher (1 065 vs 460 pg/ml). The
cancellation rate was lower (14 % vs 26 %). The use of the low dose pr
otocol gave a better ovarian response for patients with high day 3 FSH
, Large randomized studies are needed to confirm these data.