Ph. Buist et al., (S)-ALPHA-METHOXYPHENYL ACETIC-ACID - A NEW NMR CHIRAL SHIFT-REAGENT FOR THE STEREOCHEMICAL ANALYSIS OF SULFOXIDES, Tetrahedron : asymmetry, 6(1), 1995, pp. 7-10
The use of (S)-alpha-methoxyphenyl acetic acid (MPAA) as a general chi
ral H-1 NMR shift reagent for the stereochemical analysis of sulfoxide
s is demonstrated. Using this methodology, both the enantiomeric purit
y and the absolute configuration of a wide variety of sulfoxides can b
e determined.