SELECTIVE INCORPORATION OF CF2-GROUP INTO THE NATURAL COMPOUNDS MOLECULES - SYNTHESIS OF 14,14-DIFLUOROCORIOLIC ACID

Authors
KORNILOV AM KULIK IB SOROCHINSKY AE KUKHAR VP
Citation
Am. Kornilov et al., SELECTIVE INCORPORATION OF CF2-GROUP INTO THE NATURAL COMPOUNDS MOLECULES - SYNTHESIS OF 14,14-DIFLUOROCORIOLIC ACID, Tetrahedron : asymmetry, 6(1), 1995, pp. 199-206
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
1
Year of publication
1995
Pages
199 - 206
Database
ISI
SICI code
0957-4166(1995)6:1<199:SIOCIT>2.0.ZU;2-3
Abstract
The difluorides obtained in the reaction of DAST with appropriate keto nes could serve as a suitable starting materials for the selective inc orporation of CF2-group into the molecules of the unsaturated chiral n atural compounds. As an example, stereoselective synthesis of (R)-14,1 4-difluoro-13-hydroxy-9(Z) ,11(E)-octadecadienoic acid [(R)-14, 14-dif luorocoriolic acid] 6 is reported.