MICROBIAL HYDROXYLATION OF SOME SYNTHETIC ARISTOTELIA ALKALOIDS

Authors
DOBLER M BORSCHBERG HJ AZERAD R
Citation
M. Dobler et al., MICROBIAL HYDROXYLATION OF SOME SYNTHETIC ARISTOTELIA ALKALOIDS, Tetrahedron : asymmetry, 6(1), 1995, pp. 213-220
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
1
Year of publication
1995
Pages
213 - 220
Database
ISI
SICI code
0957-4166(1995)6:1<213:MHOSSA>2.0.ZU;2-3
Abstract
Synthetically prepared, optically pure samples of the rare Aristotelia alkaloids (+)-makomakine (1), (-)-hobartine (4), and (+)-aristoteline (7), were exposed to twelve selected fungal strains and have been sho wn to afford, sometimes in preparatively acceptable yield, known, as w ell as hitherto unknown hydroxylated derivatives thereof.