ASYMMETRIC-SYNTHESIS OF S-(-4-AMINO-5-HEXYNOIC ACID())

Authors
MCALONAN H STEVENSON PJ
Citation
H. Mcalonan et Pj. Stevenson, ASYMMETRIC-SYNTHESIS OF S-(-4-AMINO-5-HEXYNOIC ACID()), Tetrahedron : asymmetry, 6(1), 1995, pp. 239-244
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
1
Year of publication
1995
Pages
239 - 244
Database
ISI
SICI code
0957-4166(1995)6:1<239:AOSA>2.0.ZU;2-G
Abstract
4-Amino-5-hexynoic acid is efficiently synthesised in eight steps (ove rall yield 10%) from commercially available (S)-glutamic acid. The key step was conversion of an aldehyde to an acetylene using diethylmethy diazophosphonate.