CATALYTIC ASYMMETRIC SYNTHESES OF SECONDARY ALCOHOLS USING CIS-1-AMINO-2-INDANOLS AS CHIRAL LIGANDS

Authors
DISIMONE B SAVOIA D TAGLIAVINI E UMANIRONCHI A
Citation
B. Disimone et al., CATALYTIC ASYMMETRIC SYNTHESES OF SECONDARY ALCOHOLS USING CIS-1-AMINO-2-INDANOLS AS CHIRAL LIGANDS, Tetrahedron : asymmetry, 6(1), 1995, pp. 301-306
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
1
Year of publication
1995
Pages
301 - 306
Database
ISI
SICI code
0957-4166(1995)6:1<301:CASOSA>2.0.ZU;2-9
Abstract
Both enantiomers of cis-1-amino-2-indanols (1a,b) have been used as ch iral ligands in the catalytic asymmetric reduction of ketones with BH3 SMe(2) affording secondary alcohols with enantiomeric excesses up to 95%. Furthermore, some N,N-diakyl derivatives of 1a,b catalyzed the en antioselective addition of diethylzinc to aldehydes.