Although tellurium is not regarded as a true trace element, in that th
ere is no recognized biological role for tellurium in human tissues an
d no clinical deficiency syndrome, nonetheless the amounts of telluriu
m in the human body are reported to be higher than several of the reco
gnized trace elements. This article reviews known biological effects o
f tellurium, including the rare accounts of tellurium poisoning in man
. The experimental neurotoxic effects of tellurium, in both peripheral
nerves and cerebral tissues, may serve as useful model systems for hu
man neurological diseases.